Optimization of Synthesis Process of 4-Methylquinazoline

4-Methylquinazoline was synthesized with 2-aminoacetophenone and formamide as the starting materials. The reaction conditions, including catalyst, ratio of substrates, temperature and time were optimized. Results showed that the optimal condition were as follows: Catalyst BF3-Et2O, the molar ratio of 2-aminoacetophenone: BF3-Et2O = 1:0.5, the weight ratio of 2-aminoacetophenone: formamide = 1:52, temperature 150°C, and time 6 h. Under the optimal conditions, the yield of the reaction achieved the highest (86%), which are better than the past reports.