Task-related hemodynamic responses are modulated by reward and task engagement

Cardoso, Mariana M. B. and Lima, Bruss and Sirotin, Yevgeniy B. and Das, Aniruddha and Tong, Frank (2019) Task-related hemodynamic responses are modulated by reward and task engagement. PLOS Biology, 17 (4). e3000080. ISSN 1545-7885

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Abstract

Hemodynamic recordings from visual cortex contain powerful endogenous task-related responses that may reflect task-related arousal, or “task engagement” distinct from attention. We tested this hypothesis with hemodynamic measurements (intrinsic-signal optical imaging) from monkey primary visual cortex (V1) while the animals’ engagement in a periodic fixation task over several hours was varied through reward size and as animals took breaks. With higher rewards, animals appeared more task-engaged; task-related responses were more temporally precise at the task period (approximately 10–20 seconds) and modestly stronger. The 2–5 minute blocks of high-reward trials led to ramp-like decreases in mean local blood volume; these reversed with ramp-like increases during low reward. The blood volume increased even more sharply when the animal shut his eyes and disengaged completely from the task (5–10 minutes). We propose a mechanism that controls vascular tone, likely along with local neural responses in a manner that reflects task engagement over the full range of timescales tested.

Item Type: Article
Subjects: East India Archive > Biological Science
Depositing User: Unnamed user with email support@eastindiaarchive.com
Date Deposited: 09 Jan 2023 11:05
Last Modified: 29 Apr 2024 07:51
URI: http://ebooks.keeplibrary.com/id/eprint/11

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