Microbiota Evaluation and Extracellular Cytokine Profile in Patients Affected with Intraabdominal Infection

Ferreira, João and Rezende-Neto, João and Pinto-Silva, Rogério and Souza, Jaqueline and Farias, Luiz and Carvalho, Maria and Santiago, Helton and Serufo, José and Santos, Simone (2016) Microbiota Evaluation and Extracellular Cytokine Profile in Patients Affected with Intraabdominal Infection. British Journal of Medicine and Medical Research, 15 (4). pp. 1-14. ISSN 22310614

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Abstract

Failures in the control of infectious focus may be associated with Intra-abdominal infections (IAI)-driven sepsis. We evaluated the bacterial antimicrobial profile and the cytokine production in patients with IAI in Belo Horizonte, Brazil. To the analyses, Vitek 2 bioMérieux and BD-CBA Human Inflammatory Cytokines were used. Escherichia coli, Enterococcus faecalis and Bacteroides fragilis were predominant in this cohort. Enterobacteriaceae was resistant to at least 4 different antimicrobial classes and 80.0% of Acintobacter baumannii strains to imipenem. 81.8% of Staphylococcus spp. were methicillin-resistant. Penicillin and clindamycin resistance were found in 80.0% and 26.7% of anaerobes, respectively. IL-8 was found in all IAI secretions and in 93.5% of analyzed sera; while IL-6 was identified in 93.5% of patient’s serum and in 51.6% analyzed secretions. IL-10 was detected in 53.3% of patient’s serum. Our data indicates the relevance of further cytokine profile studies to better understanding the evolution of these processes.

Item Type: Article
Subjects: East India Archive > Medical Science
Depositing User: Unnamed user with email support@eastindiaarchive.com
Date Deposited: 02 Jun 2023 06:56
Last Modified: 15 Oct 2024 11:05
URI: http://ebooks.keeplibrary.com/id/eprint/1176

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