Resistant Nephrotic Syndrome: Review of Trials Using ACTH and a Case Series of Six Patients Treated with ACTHar

Wolf, Jaime and Patel, Vishnu and Prasad, Rishi and Teehan, Geoffrey (2014) Resistant Nephrotic Syndrome: Review of Trials Using ACTH and a Case Series of Six Patients Treated with ACTHar. British Journal of Medicine and Medical Research, 5 (11). pp. 1453-1457. ISSN 22310614

[thumbnail of Wolf5112014BJMMR13992.pdf] Text
Wolf5112014BJMMR13992.pdf - Published Version

Download (196kB)

Abstract

Nephrotic syndrome (NS) is associated with edema, proteinuria, hyperlipidemia, and an increased risk for deep vein thrombosis. Therapy may include glucocorticoids, immunosuppressive therapy, and/or chemotherapy. Each is associated with significant toxicity. Adrenocorticotrophic hormone (ACTH) has been approved for treating NS since the 1950s. Both the synthetic form of ACTH (cosyntropin-ACTH 1-24) and ACTHar (ACTH1-39), a synthetic gel isolated from porcine pituitary extracts, have been used successfully in treating NS but fewer than 100 published cases of ACTHar therapy are available in the literature. Membranous nephropathy is the best studied entity. Our case series adds six new cases to the literature and strengthens the growing consensus that ACTHar may be effective in treating focal segmental glomerulosclerosis.

Item Type: Article
Subjects: East India Archive > Medical Science
Depositing User: Unnamed user with email support@eastindiaarchive.com
Date Deposited: 21 Jun 2023 09:21
Last Modified: 08 Jun 2024 09:03
URI: http://ebooks.keeplibrary.com/id/eprint/1307

Actions (login required)

View Item
View Item