Cephalosporin Resistant Pneumococcal Meningitis in a Child-A Case Report

Meningitis caused by Streptococcus pneumoniae is associated with severe morbidity and mortality. The occurrence of multi-drug resistant strains of S. pneumoniae is associated with treatment failure of pneumococcal infections. We present a case of multidrug resistant pneumococcal meningitis in a 10 month-old patient. The patient was admitted to the Department of Child Health of the Korle-Bu Teaching Hospital with high grade fever and irritability. She received an 8-day course of vancomycin after empirical treatment failure with ceftriaxone. Subsequently, she was discharged without complications on follow-up. Although resistance to ceftriaxone among Streptococcus pneumoniae in Ghana is rare, our report highlights an instance where an unusual ceftriaxone resistant isolate may be encountered as a cause of invasive disease leading to treatment failure.