Simultaneous Spectrophotometric Determination of Sacubitril and Valsartan in their Recently Approved Pharmaceutical Preparation

Attia, Khalid and Nassar, Mohammed and El-Olemy, Ahmed and Ramzy, Sherif (2018) Simultaneous Spectrophotometric Determination of Sacubitril and Valsartan in their Recently Approved Pharmaceutical Preparation. Journal of Advanced Pharmacy Research, 2 (2). pp. 133-141. ISSN 2357-0539

[thumbnail of APRH_Volume 2_Issue 2_Pages 133-141.pdf] Text
APRH_Volume 2_Issue 2_Pages 133-141.pdf - Published Version

Download (770kB)

Abstract

Three different spectrophotometric methods have been applied for simultaneous determination of sacubitril and valsartan. The developed methods are bivariate method, classical least square and principal component regression. The bivariate method is based on simple mathematic algorithm using two optimum wavelengths for the analysis of the mixture. On the other hand, two multivariate methods considering all the variables at the same time have been used to improve the quality of spectral analysis of the mixture. The proposed methods have been successfully applied for the determination of the two drugs in Entresto® tablets. Statistical comparisons between the obtained results and those obtained by the reported method have been performed showing no significant differences by applying t-test and F-test.

Item Type: Article
Subjects: East India Archive > Medical Science
Depositing User: Unnamed user with email support@eastindiaarchive.com
Date Deposited: 12 Jun 2023 06:53
Last Modified: 08 Jun 2024 09:03
URI: http://ebooks.keeplibrary.com/id/eprint/1407

Actions (login required)

View Item
View Item