Quantitative Phytochemical, Proximate Analysis and Hypolipidemic Effect of Garcinia kola

Omeh, Y. N. and Onoja, S. O. and Ezeja, M. I. and Uchendu, W. C. and Okorie, E. and Raymond, M. (2014) Quantitative Phytochemical, Proximate Analysis and Hypolipidemic Effect of Garcinia kola. British Journal of Medicine and Medical Research, 4 (36). pp. 5770-5778. ISSN 22310614

[thumbnail of Omeh4362014BJMMR12259.pdf] Text
Omeh4362014BJMMR12259.pdf - Published Version

Download (224kB)

Abstract

Aims: This study was aimed at evaluating the phytochemical and nutrient composition of G. kola seed. Also to examine the effect of G. kola seed on the serum lipid profile of fed rats.
Study Design: Quantitative phytochemical, proximate analysis and in vivo effect on serum lipid profile.
Place and Duration of Study: Department of Biochemistry, College of Natural sciences, Michael Okpara University of Agriculture, Umudike Abia State, between June 2013 and September 2013.
Methodology: The seeds were cut into small pieces, dried and ground into powder. The quantitative phytochemical and proximate nutrient analyses of the powdered sample were determined using standard methods. The lipid lowering effects of the powdered sample of G. kola determined in rats. The rats were fed with feed fortified with graded levels (5, 10, 20 and 50%) of powdered sample of G. kola for 21 consecutive days and the effects on total cholesterol, triglyceride, low density lipoprotein cholesterol (LDL-C), very low density lipoprotein cholesterol (VLDL-C) and high density lipoprotein cholesterol (HDL-C) were compared with a negative control.
Results: The seed sample produced significant (p<0.05) dose-dependent decrease in the total serum cholesterol, triglyceride, LDL-C and VLDL-C levels in fed groups of rats when compared to the control group. The seed sample also, caused significant (p<0.05) dose-dependent increase in serum HDL-C level in fed groups of rats when compared to the control groups. The phytochemical analysis showed that the sample contained tannins (5.08%), flavonoids (0.93%), saponins (2.54%) and alkaloids (5.13%). The proximate analysis of the nutrient composition of powdered G. kola seed showed the presence of moisture, ether extract (EE), crude fibre (CF), crude protein (CP), ash and nitrogen free extracts (NFE) in the following proportion 7.40, 1.48, 2.94, 3.19, 4.39 and 80.58%, respectively.
Conclusion: The sample demonstrated good lipid lowering effects which may suggest that the consumption of G. kola seed may help in the reduction of the incidence of cardiovascular diseases in patients.

Item Type: Article
Subjects: East India Archive > Medical Science
Depositing User: Unnamed user with email support@eastindiaarchive.com
Date Deposited: 05 Jul 2023 04:34
Last Modified: 02 Oct 2024 07:18
URI: http://ebooks.keeplibrary.com/id/eprint/1440

Actions (login required)

View Item
View Item