Evaluation of Antipyretic Potential of Pseudocedrela kotschyi Schweint. Harms (Meliaceae)

Akuodor, G. C. and Essien, A. D. and Essiet, G. A. and David-Oku, Essien and Akpan, J. L. and Udoh, F. V. (2012) Evaluation of Antipyretic Potential of Pseudocedrela kotschyi Schweint. Harms (Meliaceae). European Journal of Medicinal Plants, 3 (1). pp. 105-113. ISSN 22310894

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Abstract

Pseudocedrela kotschyi is used in ethnomedicinal practice for the treatment of fever, pains and inflammation. The ethanol leaf extract of the plant was investigated for antipyretic potency in rats. Yeast and amphetamine induced hyperpyrexia were used to determine the antipyretic activity. The leaf extract (50, 100 and 150 mg/kg i.p.), exhibited significant (P<0.05) dose dependent effect on the tested experimental animal models of pyrexia. The LD50 was established to be 775 mg/kg, i.p. in mice. The results obtained suggest that the ethanol leaf extract may be a promising agent for the treatment of pyrexia.

Item Type: Article
Subjects: East India Archive > Medical Science
Depositing User: Unnamed user with email support@eastindiaarchive.com
Date Deposited: 24 Jun 2023 05:18
Last Modified: 24 Oct 2024 03:52
URI: http://ebooks.keeplibrary.com/id/eprint/1523

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