World’s First Myoblast Treatment of Human Cancer Found Safe and Efficacious

Law, Peter K. and Song, Shi Jun and Lu, Ping and Gao, Yong and Ao, Mingzhang and Zhao, Hongdan and Bai, Liyun and Guo, Kang and Law, Danlin M. (2017) World’s First Myoblast Treatment of Human Cancer Found Safe and Efficacious. Open Journal of Regenerative Medicine, 06 (01). pp. 1-16. ISSN 2169-2513

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Abstract

Evolution of placental mammals over the past 160 million years witnesses the relative sparing of muscles from cancer attacks. In 1) nude mice with human gastrointestinal or lung tumors, and 2) human subjects with liver, lung or gastrointestinal tumors, intra-tumor implantation of allogeneic human myoblasts induced cancer apoptosis, inhibiting metastasis and tumor growth. We postulate four mechanisms of cancer apoptosis: a) myoblasts releasing tumor necrosis factor-α (TNF-α); b) deprivation of nutrients and oxygen; c) local inflammatory and immunologic attacks; and d) prevention from metastasis. These basic and clinical studies demonstrated preliminary safety and efficacy of intra-tumor myoblast implantation in the development of prevention and treatment for cancer, now the number one disease killer of mankind.

Item Type: Article
Subjects: East India Archive > Biological Science
Depositing User: Unnamed user with email support@eastindiaarchive.com
Date Deposited: 15 Mar 2023 12:12
Last Modified: 13 Sep 2024 07:55
URI: http://ebooks.keeplibrary.com/id/eprint/505

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