Therapeutic angiomyogenesis using human non-viral transduced VEGF165-myoblasts

Law, Peter K. and Ye, Lei and Haider, Husnain Kh. and Lu, Ping and Law, Danlin M. and Sim, Eugene K. W. (2012) Therapeutic angiomyogenesis using human non-viral transduced VEGF165-myoblasts. Open Journal of Regenerative Medicine, 01 (01). pp. 1-9. ISSN 2169-2513

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Abstract

This article reviews the scientific development of angiomyogenesis using VEGF165-myoblasts, a patented biotechnology platform in regenerative medicine associated with Human Myoblast Genome Therapy (HMGT), also known as Myoblast Transfer Therapy (MTT). VEGF165-myoblasts are the leading biologics for angiomyogenesis. This review also compares the safety and efficacy of VEGF165-myoblasts transduced using adenoviral vectors, nanoparticles or liposomes, in anticipation of their application in clinical trials in the near future. VEGF165-myoblasts are differentiated myogenic cells capable of extensive division, natural cell fusion, nucleus transfer, cell therapy and genome therapy. Following transplantation they survive, develop and function to revitalize degenerative myocardium in heart failure and ischemic cardiomyopathy animal studies. VEGF165-myoblasts are second generation products of HMGT/MTT which replenishes live cells and genetically repairs degenerating myofibers in Type II diabetes, muscular dystrophies, aging dysfunction and disfigurement. Myoblasts have also been used to enhance skin and muscle appearance in cosmetology. We envision that VEGF165-myoblasts will provide better outcome than their non-tranduced counterparts. Myoblasts are not stem cells. Their competitive advantages over stem cells are presented.

Item Type: Article
Subjects: East India Archive > Biological Science
Depositing User: Unnamed user with email support@eastindiaarchive.com
Date Deposited: 15 Mar 2023 12:11
Last Modified: 12 Sep 2024 04:51
URI: http://ebooks.keeplibrary.com/id/eprint/521

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