Human papillomavirus clustering patterns among HIVinfected and HIV-uninfected adolescent females in South Africa

Dylla, Layne and Abar, Beau and Williamson, Anna-Lise and Meiring, Tracy L. and Bekker, Linda-Gail and Adler, David H. (2017) Human papillomavirus clustering patterns among HIVinfected and HIV-uninfected adolescent females in South Africa. Journal of AIDS and HIV Research, 9 (10). pp. 202-206.

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Abstract

The global burden of disease caused by both human immunodeficiency virus (HIV) and human papillomavirus (HPV) is the greatest in the developing world, with the highest rates in sub-Saharan Africa. South African women not only have high rates of infection with HPV, but also have high rates of multiple concurrent infections with two or more HPV genotypes, and are among the world’s most vulnerable to developing invasive cervical cancer. HIV co-infection increases these risks. Understanding clustering patterns of concurrent HPV infections in this population has important implications for HPV screening and will help define vaccination strategies in the future as vaccines continue to be developed to target more HPV genotypes. Latent class analysis was used to identify four distinct patterns of HPV co-infection: individuals with at least one low risk HPV genotype, but no high-risk HPV (HR-HPV) infections; individuals with a disperse pattern of HR-HPV infections; individuals infected with members of the alpha-7 group, but not HPV-18; and individuals infected with HPV-16, but not HPV-18. In this analysis, although alpha-7 HPV infections were more prevalent among HIV-infected adolescents than their HIV-uninfected counterparts, overall clustering patterns were not different based on HIV status.

Item Type: Article
Subjects: East India Archive > Medical Science
Depositing User: Unnamed user with email support@eastindiaarchive.com
Date Deposited: 14 Mar 2023 11:58
Last Modified: 26 Oct 2024 04:05
URI: http://ebooks.keeplibrary.com/id/eprint/528

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