CREB regulates spine density of lateral amygdala neurons: implications for memory allocation

Sargin, Derya and Mercaldo, Valentina and Yiu, Adelaide P. and Higgs, Gemma and Han, Jin-Hee and Frankland, Paul W. and Josselyn, Sheena A. (2013) CREB regulates spine density of lateral amygdala neurons: implications for memory allocation. Frontiers in Behavioral Neuroscience, 7. ISSN 1662-5153

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Abstract

Neurons may compete against one another for integration into a memory trace. Specifically, neurons in the lateral nucleus of the amygdala with relatively higher levels of cAMP Responsive Element Binding Protein (CREB) seem to be preferentially allocated to a fear memory trace, while neurons with relatively decreased CREB function seem to be excluded from a fear memory trace. CREB is a ubiquitous transcription factor that modulates many diverse cellular processes, raising the question as to which of these CREB-mediated processes underlie memory allocation. CREB is implicated in modulating dendritic spine number and morphology. As dendritic spines are intimately involved in memory formation, we investigated whether manipulations of CREB function alter spine number or morphology of neurons at the time of fear conditioning. We used viral vectors to manipulate CREB function in the lateral amygdala (LA) principal neurons in mice maintained in their homecages. At the time that fear conditioning normally occurs, we observed that neurons with high levels of CREB had more dendritic spines, while neurons with low CREB function had relatively fewer spines compared to control neurons. These results suggest that the modulation of spine density provides a potential mechanism for preferential allocation of a subset of neurons to the memory trace.

Item Type: Article
Subjects: East India Archive > Biological Science
Depositing User: Unnamed user with email support@eastindiaarchive.com
Date Deposited: 17 Mar 2023 08:44
Last Modified: 13 Sep 2024 07:55
URI: http://ebooks.keeplibrary.com/id/eprint/551

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