Reduced expression of COMT in placenta correlates with term preeclampsia

Lai, Baoling and Wang, Chenhong and Zhou, Lu and Wang, Jie and Wu, Huifen (2013) Reduced expression of COMT in placenta correlates with term preeclampsia. Advances in Bioscience and Biotechnology, 04 (04). pp. 44-49. ISSN 2156-8456

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Abstract

Objective: To investigate the expression of catechol-O- methyltransferase (COMT) in placentas from term preeclampsia patients in a Chinese cohort and to analyze the relationships between COMT and mean artery pressure (MAP), serum uric acid and 24-hour urine protein. Methods: 15 term pregnant patients with preeclampsia and 15 normal pregnant women were enrolled. Clinical characteristics and placental tissue were collected. Placental COMT expression was determined by quantitative real-time PCR technique and immunohistochemistry. Results: The level of COMT mRNA in placentas from the preeclampsia group was significantly decreased than that in the normal pregnant women (0.00179 ± 0.00051 vs. 0.00289 ± 0.00066, t = 5.145, P < 0.001). Adjusted by age and body mass index (BMI), the COMT expression was negatively correlated with serum uric acid (r = ?0.660, P < 0.001), 24-hour urine protein (r = ?0.717, P < 0.001) and MAP (r = ?0.619, P < 0.001). Conclusion: The decreased expression of COMT in placentas from term preeclamptic patients and the significant relation between COMT and severity index of preeclampsia suggest that COMT may play a role in the pathogenesis of term preeclampsia.

Item Type: Article
Subjects: East India Archive > Biological Science
Depositing User: Unnamed user with email support@eastindiaarchive.com
Date Deposited: 16 Mar 2023 11:50
Last Modified: 14 Sep 2024 04:30
URI: http://ebooks.keeplibrary.com/id/eprint/555

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