A Synthesis of Substituted 1,3,4-Oxadiazole, Pyrazole Deravatives and It’s Biological Activities

D’souza, Alphonsus and Nayak, Prashant and Khandige, Prasanna Shama and Kumar, Pankaj (2021) A Synthesis of Substituted 1,3,4-Oxadiazole, Pyrazole Deravatives and It’s Biological Activities. Journal of Pharmaceutical Research International, 33 (37B). pp. 260-269. ISSN 2456-9119

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Abstract

Aim: Nicotine Substituted 1,3,4 Oxadiazole and pyrazole moieties were integrated by utilizing hydrazide as halfway .Oxadiazole were acquired by two techniques one is by utilizing PoCl3 within the sight of fragrant corrosive ,other is by utilizing carbon disulphide in the presence ofpotassium hydroxide as an impetus .Pyrazoles were likewise gotten by ehtylacetoacetate we acquired unrefined item and again it was recrystallized by utilizing alcohol.All incorporated mixtures were evaluated for Antibacterial activity and enaminones showed promising action against standard medication ciprofloxacin.

Methods: TLC on silica gel G was used to check for homogeneity of the title compound. H NMR, Mass, and IR Spectra were used to characterise these compounds, and their antibacterial activity was tested.

Results: All of these compounds, including nicotine substituted ester, hydrazide, 1,3,4 Oxadiazole, and pyrazole, showed antibacterial activity. The maximum activity of enaminones was comparable to that of the standard drug ciprofloxacin (5mcg). Compound1 showed potent antimicrobial activity

Conclusion: In the zone of inhibition studies, all six samples at MIC concentrations showed reasonable antimicrobial activity Compound1 showed very good antimicrobial activity

Item Type: Article
Subjects: East India Archive > Medical Science
Depositing User: Unnamed user with email support@eastindiaarchive.com
Date Deposited: 24 Mar 2023 09:46
Last Modified: 14 Sep 2024 04:31
URI: http://ebooks.keeplibrary.com/id/eprint/600

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