MicroRNAs in the epigenetic regulation of disease progression in Parkinson’s disease

Selvakumar, Sushmaa Chandralekha and Preethi, K. Auxzilia and Tusubira, Deusdedit and Sekar, Durairaj (2022) MicroRNAs in the epigenetic regulation of disease progression in Parkinson’s disease. Frontiers in Cellular Neuroscience, 16. ISSN 1662-5102

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Abstract

Parkinson’s disease (PD) is a multifactorial neurodegenerative condition with symptoms such as resting tremor, rigidity, bradykinesia (slowness of moment), and postural instability. Neuroinflammation plays a significant part in the onset and progression of neurodegeneration in a wide range of disorders, including PD. The loss of dopaminergic neurons in the substantia nigra (SN) is thought to be the primary cause of PD disease progression. However, other neurotransmitter systems like serotoninergic, glutamatergic, noradrenergic, adrenergic, cholinergic, tryptaminergic, and peptidergic appear to be affected as well. Epigenetic regulation of gene expression is emerging as an influencing factor in the pathophysiology of PD. In recent years, epigenetic regulation by microRNAs (miRNAs) has been discovered to play an important function in the disease progression of PD. This review explores the role of miRNAs and their signaling pathways in regulating gene expression from development through neurodegeneration and how these mechanisms are linked to the pathophysiology of PD, emphasizing potential therapeutic interventions.

Item Type: Article
Subjects: East India Archive > Medical Science
Depositing User: Unnamed user with email support@eastindiaarchive.com
Date Deposited: 30 Mar 2023 08:47
Last Modified: 23 May 2024 07:31
URI: http://ebooks.keeplibrary.com/id/eprint/622

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