Microglia in Alzheimer’s Disease: A Target for Therapeutic Intervention

Zhang, Guimei and Wang, Zicheng and Hu, Huiling and Zhao, Meng and Sun, Li (2021) Microglia in Alzheimer’s Disease: A Target for Therapeutic Intervention. Frontiers in Cellular Neuroscience, 15. ISSN 1662-5102

[thumbnail of pubmed-zip/versions/1/package-entries/fncel-15-749587/fncel-15-749587.pdf] Text
pubmed-zip/versions/1/package-entries/fncel-15-749587/fncel-15-749587.pdf - Published Version

Download (2MB)

Abstract

Alzheimer’s disease (AD) is one of the most common types of age-related dementia worldwide. In addition to extracellular amyloid plaques and intracellular neurofibrillary tangles, dysregulated microglia also play deleterious roles in the AD pathogenesis. Numerous studies have demonstrated that unbridled microglial activity induces a chronic neuroinflammatory environment, promotes β-amyloid accumulation and tau pathology, and impairs microglia-associated mitophagy. Thus, targeting microglia may pave the way for new therapeutic interventions. This review provides a thorough overview of the pathophysiological role of the microglia in AD and illustrates the potential avenues for microglia-targeted therapies, including microglial modification, immunoreceptors, and anti-inflammatory drugs.

Item Type: Article
Subjects: East India Archive > Medical Science
Depositing User: Unnamed user with email support@eastindiaarchive.com
Date Deposited: 11 Apr 2023 07:00
Last Modified: 14 Sep 2024 04:30
URI: http://ebooks.keeplibrary.com/id/eprint/795

Actions (login required)

View Item
View Item