The effects of in utero exposure to antiretroviral therapy (ART) on the language abilities of HIV exposed uninfected infants

Tarryn, Stevens and Sheree, Schwartz and Anniah, Mupawose and Sharon, Moonsamy and Vivian, Black (2017) The effects of in utero exposure to antiretroviral therapy (ART) on the language abilities of HIV exposed uninfected infants. Journal of AIDS and HIV Research, 9 (8). pp. 164-170. ISSN 2141-2359

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Abstract

This study investigates the possible effects of in-utero antiretroviral therapy (ART) exposure on early language development in HIV exposed uninfected infants. 27 mother-infant pairs consented to the study. Early language development was assessed using the Rossetti Infant Toddler Language Scale. Descriptive statistics were used to describe the caregiver and infant characteristics, as well as the language and communication abilities of infants exposed to in-utero ART. T-test statistics compared the early linguistic development of infants conceived while taking efavirenz and infants that were conceived on a nevirapine or protease-inhibitor (PI lopinavir/ritonavir) containing regimen. Similarly, t-tests or ANOVA statistics assessed maternal and infant characteristics associated with total language development. Results obtained in the study revealed no significant differences between the overall language abilities of infants exposed to regimen containing nevirapine or a PI versus regimen that contained efavirenz. The comparison of mean total Rossetti Infant-Toddler Language scores by infant age and maternal and infant characteristics revealed no significant association between variables except for hospitalization. Results obtained suggest that overall language development may not be significantly affected by in utero ART exposure however, further research is warranted to assess whether these infants are at an increased risk of late language emergence.

Item Type: Article
Subjects: East India Archive > Medical Science
Depositing User: Unnamed user with email support@eastindiaarchive.com
Date Deposited: 13 Apr 2023 07:30
Last Modified: 24 Sep 2024 11:27
URI: http://ebooks.keeplibrary.com/id/eprint/818

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