Current Biochemical Applications and Future Prospects of Chlorotoxinin Cancer Diagnostics and Therapeutics

Khanyile, Sbonelo and Masamba, Priscilla and Oyinloye, Babatunji Emmanuel and Mbatha, Londiwe Simphiwe and Kappo, Abidemi Paul (2019) Current Biochemical Applications and Future Prospects of Chlorotoxinin Cancer Diagnostics and Therapeutics. Advanced Pharmaceutical Bulletin, 9 (4). pp. 510-520. ISSN 2228-5881

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Abstract

Chlorotoxin (CTX) is a minute 4 kDa protein made up of 36 amino acid residues, commonly known for its binding affinity to chloride channels and matrix metalloproteinase-2 (MMP-2) of glioma tumors of the spine and brain. This property and the possibility of conjugating this peptide to nanoparticles have enabled its diverse use in various biotechnological and biomedical applications for cancer treatment, such as in tumor imaging and radiotherapy. Because of the fascinating biological properties CTX possesses, elucidating its mechanism of action may hold promise for the development of new and effective therapeutic drugs, as well as more sensitive and highly specific cancer-screening kits. This article therefore reviews the currently known applications of CTX and suggests diverse ways in which it can be applied for the design of improved drugs and diagnostic tools for cancer.

Item Type: Article
Subjects: East India Archive > Medical Science
Depositing User: Unnamed user with email support@eastindiaarchive.com
Date Deposited: 14 Apr 2023 09:48
Last Modified: 21 Sep 2024 04:36
URI: http://ebooks.keeplibrary.com/id/eprint/827

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