Synthesis of Co2+/Zn2+ Impregnated Bentonite-Chitosan Composite Hetero-catalyst and Application of Principal Component Analysis to Evaluate its Catalytic Activity for the Synthesis of Nitrogen Containing 5 and 6 Membered Heterocyclic Compounds

A hetero-catalyst, Co2+ and Zn2+ impregnated Bentonite-Chitosan composite (Co2+-BCC and Zn2+-BCC) has been developed separately and characterized using scanning electron microscope (SEM), for the synthesis of a different class of nitrogen containing 5 and 6 membered heterocyclic compounds. Co2+-BCC showed high catalytic activity for octahydroquinazolinones and imidazoles; and Zn2+-BCC for 1,4-dihydropyridines and benzimidazoles. Isoxazoles were synthesized in excellent yield by both Co2+-BCC and Zn2+-BCC. Different ratios of Co2+/Zn2+-BCC were analyzed to achieve high percentage yield of heterocyclic compounds. Principal component analysis was performed to further extract the systematic variation and evaluate the catalytic efficacy of Co2+-BCC and Zn2+-BCC for the different class of nitrogen-containing heterocyclic compounds.