Detection and allergen analysis of serum IgE in pediatric patients with chronic urticaria

Objective: To detect the serum IgE and allergen-specific IgE levels of pediatric patients with chronic urticaria, and to analyze the distribution characteristics of allergens.

Methods: Ninety-six patients with chronic urticaria admitted in our hospital, which were not administered antihistamine 10 days before detection or glucocorticoid 20 days before detection, were selected. Their serum IgE levels were measured and 34 antigens were analyzed.

Results: Ninety-two of the ninety-six patients were detected as serum IgE positive (positive rate: 95.83%). The positive serum IgE levels did not significantly change along with season (P>0.05). The positive detection rate of antigens was 95.83% (92/96), and the top five potent antigens included house dust mite, flour mite, histamine, egg yolk and egg white.

Conclusion: Dust mite, as the most common antigen for pediatric patients with chronic urticaria, is prone to variations of specific IgE positive rate along with season. The results may be associated with the persistent warm and humid climate in this region.